BIOMO301-19B (HAM)

Advanced Biochemistry

15 Points

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Division of Health Engineering Computing & Science
School of Science


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Paper Description

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This paper is targeted at students interested in biochemistry, plant and animal physiology, biotechnology, genetics, microbiology and chemistry. We will build on the principles of biochemistry introduced in BIOL251 to consider metabolic regulation through the molecular control of enzyme activity and cellular communication, including the trafficking of proteins between organelles, cellular stress responses and cell-death, as well as human diseases (e.g. diabetes). We will also examine how protein structures are determined, the process of nucleotide metabolism and transcription and features of molecular motors (such as the ATP synthase). Students will also be required to evaluate and submit a written report on recent findings in Biochemistry and Molecular cell biology.

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Paper Structure

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This paper is taught through lectures and a written assignment.

Practical classes:

PRACTICAL CLASSES WILL RUN from 2nd July to 10th September

Mon 2.00-5.00pm, Tue 2.00-5.00pm – students will be assigned to one of these two streams.

The practical work is designed to give experience in learning, from published methods and manufacturers' instructions, a range of techniques commonly used in modern biochemistry laboratories. Labs will be run in R.1.22

You should note that the practical classes are an integral part of the course.

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Learning Outcomes

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Students who successfully complete the course should be able to:

  • Explain the molecular mechanisms responsible for the movement of proteins from cytoplasm to mitochondria, endoplasmic reticulum and nucleus.
    Linked to the following assessments:
  • Define the key steps and cellular molecular machines responsible for the degradation of intra-cellular proteins.
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  • Explain how heat shock proteins assist mammalian cells to survive cellular stress and define the key steps and components involved in programmed cellular death (apoptosis).
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  • Define key steps during cellular signal transduction by using Insulin and its receptor activation to show how glucose transporters are activated in muscle and adipose cells.
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  • Explain how glucose homeostasis is maintained in mammalian cells and define the metabolic basis of Diabetes Mellitus.
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  • Explain how protein structures are experimentally determined
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  • Understand the processes of nucleotide metabolism
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  • Describe the main features of a range of molecular motors
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  • Present a written report from information obtained from a review of a research paper from the Biochemical literature
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  • Perform a range of practical laboratory techniques commonly used Biochemistry;

    be able to perform unfamiliar practical laboratory techniques by following procedures described in published papers or provided by manufacturers of laboratory equipment; calculate results and present these in tables and graphs; explain which is the best method to use in various circumstances where there is more than one method available.

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50% on final examination, 10% on the written report, 10% on the laboratory course and 30% on two tests.

The two 50 minute tests will be held in the usual lecture time and place on 2nd of August and `20th of September.

Due dates for the written reports are shown on the timetable attached to this outline. These reports will need to be submitted on line via the course Moodle site and will be subjected to Turnitin software check. Lateness in handing in reports will be penalised by loss of 10% of the mark per working day.

Any queries related to assessment should be directed to Dr. Ryan Martinus.

Note. A metabolic pathway chart may be taken into tests and the final examination. This must be unmarked other than with the student's name and with coloured highlighting of the arrows printed on the chart.

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Assessment Components

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The internal assessment/exam ratio (as stated in the University Calendar) is 50:50. There is no final exam. The final exam makes up 50% of the overall mark.

The internal assessment/exam ratio (as stated in the University Calendar) is 50:50 or 0:0, whichever is more favourable for the student. The final exam makes up either 50% or 0% of the overall mark.

Component DescriptionDue Date TimePercentage of overall markSubmission MethodCompulsory
1. Practical Work
  • Hand-in: In Lab
2. Two Tests
  • In Class: In Lecture
3. Written report
  • Online: Submit through Moodle
4. Exam
Assessment Total:     100    
Failing to complete a compulsory assessment component of a paper will result in an IC grade
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Required and Recommended Readings

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Required Readings

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Text book: Garnett & Grisham, 5th Edn, “Biochemistry” (Saunders).

Lab and Lecture powerpoints: A copy of the lab manual can be picked up from the Campus Copy Shop (prior to the start of the labs). All lecture powerpoints will be on Moodle.

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Online Support

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This paper has a Moodle page ( where you will be able to access pdfs of lecture notes and powerpoints, lecture recordings, and assessment materials. There are also discussion forums where you can both ask and answer questions.

PLEASE NOTE: Moodle will be used for class notices etc and it is your responsibility to check the site regularly. Instructions provided on Moodle and in lectures are considered to be given to the class as a whole.

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Lectures: 22 hours contact, Tutorials: 9 hours contact, Laboratory classes 18 hours contact, Assessment: (Tests 2 hours contact, Examination 3 hours contact).

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Linkages to Other Papers

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Prerequisite papers: BIOMO201 or BIOL251




Restricted papers: BIOL351 and ENMP425

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